Pharmacologic Management of Excessive Daytime Sleepiness

Taisuke Ono; Shinichi Takenoshita; Seiji Nishino

doi:10.1016/j.jsmc.2022.06.012

Pharmacologic Management of Excessive Daytime Sleepiness

Sleep Med Clin. 2022 Sep;17(3):485-503. doi: 10.1016/j.jsmc.2022.06.012. Epub 2022 Sep 8.

Authors

Taisuke Ono¹, Shinichi Takenoshita², Seiji Nishino²

Affiliations

¹ Sleep and Circadian Neurobiology Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA; Department of Geriatric Medicine, Kanazawa Medical University School of Medicine, Ishikawa, Japan. Electronic address: taisukeo@kanazawa-med.ac.jp.
² Sleep and Circadian Neurobiology Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.

PMID: 36150809
DOI: 10.1016/j.jsmc.2022.06.012

Abstract

Excessive daytime sleepiness (EDS) is defined as "irresistible sleepiness in a situation when an individual would be expected to be awake, and alert." EDS has been a big concern not only from a medical but also from a public health point of view. Patients with EDS have the possibility of falling asleep even when they should wake up and concentrate, for example, when they drive, play sports, or walk outside. In this article, clinical characteristics of common hypersomnia and pharmacologic treatments of each hypersomnia are described.

Keywords: Excessive daytime sleepiness (EDS); Idiopathic hypersomnia; Modafinil; Narcolepsy; Pitolisant; Sodium oxybate; Solriamfetol; Stimulants.

Publication types

Review

MeSH terms

Disorders of Excessive Somnolence* / drug therapy
Humans
Narcolepsy*
Sleepiness
Wakefulness