Drugs Used in Narcolepsy and Other Hypersomnias

Sleep Med Clin. 2022 Sep;17(3):399-405. doi: 10.1016/j.jsmc.2022.06.005. Epub 2022 Sep 1.

Abstract

Lifestyle adjustment, in combination with symptomatic pharmacologic treatment, allows most patients, particularly those with an inability to stay awake during the day, to live a relatively normal life. New pharmacologic substances show encouraging results in phase 2 and 3 studies to improve the current situation. More dedicated studies in IH, particularly in those who suffer from an increased need for sleep, are needed.

Keywords: Idiopathic hypersomnia; Narcolepsy; Nonpharmacologic treatment; Pharmacologic treatment; Pitolisant; Sodium oxybate; Stimulants.

Publication types

  • Review

MeSH terms

  • Disorders of Excessive Somnolence* / drug therapy
  • Humans
  • Narcolepsy* / drug therapy
  • Sleep
  • Wakefulness