The role of Actopaxin in tumor metastasis

Manrong Qu; Kehui Yu; Aziz Ur Rehman Aziz; Hangyu Zhang; Zhengyao Zhang; Na Li; Bo Liu

doi:10.1016/j.pbiomolbio.2022.09.006

The role of Actopaxin in tumor metastasis

Prog Biophys Mol Biol. 2022 Nov:175:90-102. doi: 10.1016/j.pbiomolbio.2022.09.006. Epub 2022 Sep 21.

Authors

Manrong Qu¹, Kehui Yu¹, Aziz Ur Rehman Aziz¹, Hangyu Zhang¹, Zhengyao Zhang², Na Li³, Bo Liu⁴

Affiliations

¹ School of Biomedical Engineering, Dalian University of Technology, Key Laboratory for Integrated Circuit and Biomedical Electronic System of Liaoning Province, Dalian, 116024, China.
² School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, 124221, China.
³ School of Biomedical Engineering, Dalian University of Technology, Key Laboratory for Integrated Circuit and Biomedical Electronic System of Liaoning Province, Dalian, 116024, China. Electronic address: lina316@dlut.edu.cn.
⁴ School of Biomedical Engineering, Dalian University of Technology, Key Laboratory for Integrated Circuit and Biomedical Electronic System of Liaoning Province, Dalian, 116024, China. Electronic address: lbo@dlut.edu.cn.

PMID: 36150525
DOI: 10.1016/j.pbiomolbio.2022.09.006

Abstract

Actopaxin is a newly discovered focal adhesions (FAs) protein, actin-binding protein and pseudopodia-enriched molecule. It can not only bind to a variety of FAs proteins (such as Paxillin, ILK and PINCH) and non-FAs proteins (such as TESK1, CdGAP, β2-adaptin, G3BP2, ADAR1 and CD29), but also participates in multiple signaling pathways. Thus, it plays a crucial role in regulating important processes of tumor metastasis, including matrix degradation, migration, and invasion, etc. This review covers the latest progress in the structure and function of Actopaxin, its interaction with other proteins as well as its involvement in regulating tumor development and metastasis. Additionally, the current limitations for Actopaxin related studies and the possible research directions on it in the future are also discussed. It is hoped that this review can assist relevant researchers to obtain a deep understanding of the role that Actopaxin plays in tumor progression, and also enlighten further research and development of therapeutic approaches for the treatment of tumor metastasis.

Keywords: Actopaxin; FAs; Focal adhesions; Signaling pathway; Tumor metastasis; α-Parvin.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Actinin* / metabolism
Cell Movement
Focal Adhesions / metabolism
Humans
Microfilament Proteins / chemistry
Microfilament Proteins / metabolism
Neoplasms* / metabolism

Substances

Actinin
Microfilament Proteins