The neutralisation of structurally varied chemical warfare agent simulants (blister and nerve agents) and pesticides (Paraoxon) with the assistance of high pressure is reported. Chloroethyl amines and sulfides (nitrogen and sulfur mustards), phosphonothioates (V-series nerve agents) and phosphates (pesticide) readily react with simple nucleophilic scavengers (alcohols, amines) at P > 14 000 bar.