Treatment with cefiderocol in K. pneumoniae KPC nosocomial external ventricular drainage meningitis: A brief report

Francesco Colombo; Ali Waheed; Sandro Panese; Claudio Scarparo; Maria Solinas; Saverio Giuseppe Parisi; Nicholas Geremia

doi:10.53854/liim-3003-15

Treatment with cefiderocol in K. pneumoniae KPC nosocomial external ventricular drainage meningitis: A brief report

Infez Med. 2022 Sep 1;30(3):454-458. doi: 10.53854/liim-3003-15. eCollection 2022.

Authors

Francesco Colombo¹, Ali Waheed¹, Sandro Panese², Claudio Scarparo³, Maria Solinas³, Saverio Giuseppe Parisi¹, Nicholas Geremia²

Affiliations

¹ Department of Molecular Medicine, University of Padova, Padua, Italy.
² Unit of Infectious Diseases, Department of Clinical Medicine, Ospedale dell'Angelo, Venice, Italy.
³ Unit of Microbiology and Virology, Ospedale dell'Angelo, Department of Medical Direction, Ospedale "dell'Angelo", Venice, Italy.

Abstract

We report the case of successful use of cefiderocol (FDC) in a Carbapenemase Producing K. pneumoniae (CPKP) post-surgical meningitis in a 44-year-old man treated with antimicrobial therapy and external ventricular drainage (EVD). The patient was known for being colonised by CPKP; for this reason, therapy with ceftazidime/avibactam (CZA) plus fosfomycin and linezolid was started. After an initial response a CZA resistant CPKP strain was isolated from CSF culture, so the antibiotic therapy was modified to FDC with trimethoprim/sulfamethoxazole for 14 days, and EVD was replaced. A complete recovery was obtained. This is the first case report describing FDC administration in CPKP meningitis.

Keywords: Klebsiella pneumoniae; carbapenemase; cefiderocol; enterobacterales; meningitidis.

Publication types

Case Reports