Decreased resting-state functional connectivity of the habenula-cerebellar in a major depressive disorder

Ju-Yeon Jung; Seo-Eun Cho; Nambeom Kim; Chang-Ki Kang; Seung-Gul Kang

doi:10.3389/fpsyt.2022.925823

Decreased resting-state functional connectivity of the habenula-cerebellar in a major depressive disorder

Front Psychiatry. 2022 Sep 6:13:925823. doi: 10.3389/fpsyt.2022.925823. eCollection 2022.

Authors

Ju-Yeon Jung¹, Seo-Eun Cho², Nambeom Kim³, Chang-Ki Kang⁴, Seung-Gul Kang²

Affiliations

¹ Department of Health Science, Gachon University Graduate School, Incheon, South Korea.
² Department of Psychiatry, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea.
³ Department of Biomedical Engineering Research Center, Gachon University, Incheon, South Korea.
⁴ Department of Radiological Science, College of Health Science, Gachon University, Incheon, South Korea.

Abstract

Background: In animal experiments, the habenula and septal nuclei are known as the key brain areas of depression. However, there are few magnetic resonance imaging (MRI) studies on the functional connectivity between these areas and the subcortical areas in humans with major depression. We aimed to investigate the difference in resting-state functional connectivity (RSFC) among the major regions of interest (ROI) in the subcortical areas, including both the habenula and septal nuclei.

Methods: We performed the seed-to-voxel analysis to investigate the RSFC between both the habenula and septal nucleus, as well as other subcortical regions. Furthermore, ROI-to-ROI analysis was performed among the combinations of ROI pairs in the subcortical areas.

Results: The seed-to-voxel analysis showed a lower RSFC between the left habenula and the cerebellum in major depressive disorder (MDD) than in healthy controls (HCs). As a result of ROI-to-ROI analysis in subcortical areas, a total of 31 pairs of FCs in the MDD group showed a lower RSFC than in the HCs group.

Conclusion: This study revealed a lower RSFC between the left habenula and cerebellum in patients with MDD and reduced RSFC among numerous subcortical areas. These new findings on the neural circuitry of MDD might contribute to an in-depth understanding of depression.

Keywords: cerebellum; habenula; major depressive disorder; restring state functional connectivity; septal nuclei; subcortical areas.