D-Dimer-to-Albumin Ratio: A Novel Indicator to Predict Poor Outcomes in Patients with HBV-Associated Decompensated Cirrhosis

Biomed Res Int. 2022 Sep 13:2022:9062383. doi: 10.1155/2022/9062383. eCollection 2022.

Abstract

Background: The purpose of the present study was to investigate the impact of D-dimer-to-albumin ratio (DAR) on outcomes in patients with hepatitis B virus-associated decompensated cirrhosis (HBV-DeCi).

Methods: A total of 172 HBV-DeCi patients were enrolled. Logistic regression was used to explore the association between DAR and 30-day mortality. The area under the receiver operating characteristic curve (AUC) was used to evaluate the performance of DAR for predicting mortality.

Results: The 30-day mortality was 19.8%. DAR was clearly higher in the nonsurvivors compared with the survivors, and increasing DAR was associated with an increasing risk of death. DAR was independently associated with mortality and its AUC for mortality was equivalent to that for Model for End-Stage Liver Disease score.

Conclusions: DAR may be a potential prognostic marker for mortality in HBV-DeCi patients.

MeSH terms

  • Albumins
  • End Stage Liver Disease* / complications
  • Fibrin Fibrinogen Degradation Products
  • Hepatitis B virus
  • Hepatitis B, Chronic* / complications
  • Humans
  • Liver Cirrhosis / complications
  • Prognosis
  • ROC Curve
  • Retrospective Studies
  • Severity of Illness Index

Substances

  • Albumins
  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D