Zirconium Molybdate Nanocomposites' Sensing Platform for the Sensitive and Selective Electrochemical Detection of Adefovir

Molecules. 2022 Sep 15;27(18):6022. doi: 10.3390/molecules27186022.

Abstract

Adefovir (ADV) is an anti-retroviral drug, which can be used to treat acquired immune deficiency syndrome (AIDS) and chronic hepatitis B (CHB), so its quantitative analysis is of great significance. In this work, zirconium molybdate (ZrMo2O8) was synthesized by a wet chemical method, and a composite with multi-walled carbon nanotubes (MWCNTs) was made. ZrMo2O8-MWCNTs composite was dropped onto the surface of a glassy carbon electrode (GCE) to prepare ZrMo2O8-MWCNTs/GCE, and ZrMo2O8-MWCNTs/GCE was used in the electrochemical detection of ADV for the first time. The preparation method is fast and simple. The materials were characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and cyclic voltammetry (CV). It was electrochemically analysed by differential pulse voltammetry (DPV). Compared with single-material modified electrodes, ZrMo2O8-MWCNTs/GCE showed a vastly improved electrochemical response to ADV. Moreover, the sensor complements the study of the electrochemical detection of ADV. Under optimal conditions, the proposed electrochemical method showed a wide linear range (from 1 to 100 μM) and a low detection limit (0.253 μM). It was successfully tested in serum and urine. In addition, the sensor has the advantages of a simple preparation, fast response, good reproducibility and repeatability. It may be helpful in the potential applications of other substances with similar structures.

Keywords: Adefovir; electrochemical detection; multi-walled carbon nanotubes; serum; urine; zirconium molybdate.

MeSH terms

  • Adenine / analogs & derivatives
  • Electrochemical Techniques / methods
  • Electrodes
  • Limit of Detection
  • Molybdenum
  • Nanocomposites* / chemistry
  • Nanotubes, Carbon* / chemistry
  • Organophosphonates
  • Reproducibility of Results
  • Zirconium

Substances

  • Nanotubes, Carbon
  • Organophosphonates
  • zirconium molybdate
  • adefovir
  • Molybdenum
  • Zirconium
  • Adenine

Grants and funding

The authors gratefully acknowledge the financial support of the Special Project of 2022 Social Development and Transformation of Scientific and Technological Achievements (No. 51318, Zhuzhou Municipal Science and Technology Bureau (2020, No. 30 and 2021, No. 44), Doctoral Program Construction of Hunan University of Technology, Postgraduates Innovation Fund of HUT, the NSFC (61703152), Hunan Provincial Natural Science Foundation (2018JJ34) and Project of Science and Technology Department of Hunan Province (2021JJ50035).