Procalcitonin as a Candidate Biomarker for Malarial Infection and Severe Malaria: A Meta-Analysis

Aongart Mahittikorn; Kwuntida Uthaisar Kotepui; Wanida Mala; Polrat Wilairatana; Manas Kotepui

doi:10.3390/ijerph191811389

Procalcitonin as a Candidate Biomarker for Malarial Infection and Severe Malaria: A Meta-Analysis

Int J Environ Res Public Health. 2022 Sep 9;19(18):11389. doi: 10.3390/ijerph191811389.

Authors

Aongart Mahittikorn¹, Kwuntida Uthaisar Kotepui², Wanida Mala², Polrat Wilairatana³, Manas Kotepui²

Affiliations

¹ Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
² Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat 80160, Thailand.
³ Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

Abstract

Procalcitonin (PCT), as a marker of malaria severity, remains to be investigated. The present study collated and compared the levels of PCT between patients with severe malaria, uncomplicated malaria, and control participants to assess their role in predicting malaria infection and disease severity. The systematic review was registered at PROSPERO with registration number CRD42021297243. The search for relevant studies that reported PCT in patients with malaria was performed in PubMed, Scopus, and Web of Science. The following meta-analyses were conducted; (1) the pooled mean PCT levels in patients with severe and uncomplicated malaria, and (2) the pooled mean difference in PCT levels between patients with severe and uncomplicated malaria. Fifteen studies were included for qualitative and quantitative syntheses. The meta-analysis results show that the pooled mean PCT levels in patients with uncomplicated malaria were 3.92 ng/mL (95% CI: 2.26-5.58 ng/mL, I²: 96.5, five studies), whereas the pooled mean PCT levels in patients with severe malaria were 14.13 ng/mL (95% CI: 8.75-19.5 ng/mL, I²: 92.6, six studies). The meta-analysis showed that patients with severe malaria had an equal mean of PCT compared to those with uncomplicated malaria when the random-effects model was used (p: 0.055, weighted mean difference: 6.93, 95% CI: -0.16-14.02, I²: 84.6%, four studies). There were probable correlations between the level of parasitemia, immunity level, and possibly bacterial or other parasitic co-infection that could affect the PCT level among different clinical severities of malaria. Therefore, the PCT level alone does not seem to be a suitable biomarker to discriminate the severe/uncomplicated or infected/uninfected cases. Further studies should investigate the increased PCT levels in combination with other markers in association with malaria infection and severity.

Keywords: Plasmodium; malaria; procalcitonin; severe malaria.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Coinfection*
Humans
Malaria* / diagnosis
Procalcitonin
Severity of Illness Index

Substances

Biomarkers
Procalcitonin

Grants and funding

This research was financially supported by the new strategic research project (P2P) fiscal year 2022, Walailak University, Thailand. This research was partially supported by Mahidol University, Thailand. The funders played no role in collecting, analyzing, and interpreting the data.