Autologous Platelet Concentrates (APCs) for Hard Tissue Regeneration in Oral Implantology, Sinus Floor Elevation, Peri-Implantitis, Socket Preservation, and Medication-Related Osteonecrosis of the Jaw (MRONJ): A Literature Review

Eitan Mijiritsky; Haya Drora Assaf; Roni Kolerman; Luca Mangani; Vasilena Ivanova; Stefan Zlatev

doi:10.3390/biology11091254

Autologous Platelet Concentrates (APCs) for Hard Tissue Regeneration in Oral Implantology, Sinus Floor Elevation, Peri-Implantitis, Socket Preservation, and Medication-Related Osteonecrosis of the Jaw (MRONJ): A Literature Review

Biology (Basel). 2022 Aug 23;11(9):1254. doi: 10.3390/biology11091254.

Authors

Eitan Mijiritsky¹, Haya Drora Assaf², Roni Kolerman³, Luca Mangani⁴, Vasilena Ivanova⁵, Stefan Zlatev⁶

Affiliations

¹ Head and Neck Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, Department of Otolaryngology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 699350, Israel.
² Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 9190401, Israel.
³ Department of Periodontology and Oral Implantology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel.
⁴ Department of Translational Medicine and Clinical Science, University of Tor Vegata, 00133 Rome, Italy.
⁵ Oral Surgery Department, Faculty of Dental Medicine, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.
⁶ CAD/CAM Center of Dental Medicine at the Research Institute, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria.

Abstract

Over recent years, the usage of autologous platelet concentrates (APCs) has risen in hard tissue regeneration and oral implantology. The purpose of the present review is to offer an overview of the use of three APC techniques in dentistry: platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF). A narrative summary of articles published between January 2011 and April 2022 is provided. The PubMed, Cochrane Library, Scopus, and Embase databases were used to conduct the search. The following keywords were used in the preliminary: "VEGF", "TGF-b1", "PRP", "PRF", "CGF", AND "sinus augmentation" OR "implants" OR "peri-implantitis" OR "socket preservation" OR "MRONJ". A total of 82 articles was finally included. The review then takes into account the application of the three techniques in different areas of treatment-including oral implantology, sinus floor elevation, peri-implantitis, socket preservation, and medication-related osteonecrosis of the jaw (MRONJ)-as well as their advantages and disadvantages.

Keywords: CGF; PRF; PRP; autologous platelet concentrates; bone regeneration; dental implants.

Publication types

Review

Grants and funding

This research received no external funding.