Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations

James J Hobson; Paul Curley; Alison C Savage; Amer Al-Khouja; Marco Siccardi; Charles Flexner; Caren Freel Meyers; Andrew Owen; Steve P Rannard

doi:10.1039/c9na00529c

Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations

Nanoscale Adv. 2019 Oct 12;1(11):4301-4307. doi: 10.1039/c9na00529c. eCollection 2019 Nov 5.

Authors

James J Hobson¹, Paul Curley², Alison C Savage¹, Amer Al-Khouja³, Marco Siccardi², Charles Flexner^{3

4}, Caren Freel Meyers³, Andrew Owen², Steve P Rannard¹

Affiliations

¹ Department of Chemistry, University of Liverpool Crown Street Liverpool L69 7ZD UK srannard@liv.ac.uk.
² Department of Molecular and Clinical Pharmacology, University of Liverpool Block H, 70 Pembroke Place Liverpool L69 3GF UK.
³ Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine 725 North Wolfe St. Baltimore MD 21205 USA.
⁴ Department of Medicine, The Johns Hopkins University School of Medicine 575 Osler Building, 600 N. Wolfe St. Baltimore MD 21287 USA.

Abstract

The facile formation of drug nanoparticles in injectable/ingestible oils, of water-soluble antiretroviral tenofovir disoproxil fumarate, using a novel nanoprecipitation is presented with studies showing drug release into relevant aqueous media.