De Novo Diagnosis of Lymphocytic Colitis After SARS-CoV-2 Vaccination

Preston Lee; Mike T Wei; John Gubatan; Erna Forgó; Gerald J Berry; Rahul Verma; Shai Friedland

doi:10.14309/crj.0000000000000849

De Novo Diagnosis of Lymphocytic Colitis After SARS-CoV-2 Vaccination

ACG Case Rep J. 2022 Sep 7;9(9):e00849. doi: 10.14309/crj.0000000000000849. eCollection 2022 Sep.

Authors

Preston Lee^{1

2}, Mike T Wei¹, John Gubatan¹, Erna Forgó³, Gerald J Berry³, Rahul Verma^{1

4}, Shai Friedland¹

Affiliations

¹ Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA.
² Santa Clara Valley Medical Center, San Jose, CA.
³ Department of Pathology, Stanford University School of Medicine, Stanford, CA.
⁴ Menlo Medical Clinic, Menlo Park, CA.

Abstract

SARS-CoV-2 mRNA vaccines are safe and effective for most patients. Gastrointestinal complications reported after vaccination have included gastroparesis and inflammatory bowel disease flares. In this study, we present a unique case of lymphocytic colitis that occurred in a healthy middle-aged man after Moderna SARS-CoV-2 mRNA vaccination. This reveals an unexpected complication of a mRNA vaccine that presented as worsening diarrhea after vaccination in a dose-dependent pattern. Caregivers should be aware of lymphocytic colitis as a possible complication of the Moderna vaccine and monitor those patients closely for symptom resolution.

Publication types

Case Reports