Nonlinear association of 1,5-anhydroglucitol with the prevalence and severity of coronary artery disease in chinese patients undergoing coronary angiography

Ruiyue Yang; Wenduo Zhang; Xinyue Wang; Siming Wang; Qi Zhou; Hongxia Li; Hongna Mu; Xue Yu; Fusui Ji; Jun Dong; Wenxiang Chen

doi:10.3389/fendo.2022.978520

Nonlinear association of 1,5-anhydroglucitol with the prevalence and severity of coronary artery disease in chinese patients undergoing coronary angiography

Front Endocrinol (Lausanne). 2022 Sep 5:13:978520. doi: 10.3389/fendo.2022.978520. eCollection 2022.

Authors

Ruiyue Yang¹, Wenduo Zhang², Xinyue Wang², Siming Wang¹, Qi Zhou¹, Hongxia Li¹, Hongna Mu¹, Xue Yu², Fusui Ji², Jun Dong¹, Wenxiang Chen^{1

3}

Affiliations

¹ The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, China.
² Department of Cardiology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
³ National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, China.

Abstract

Background: Postprandial hyperglycemia plays an important role in the pathogenesis of coronary artery disease (CAD). The aim of this study is to determine the associations of 1,5-Anhydroglucitol (1,5-AG), which reflects circulating glucose fluctuations, with the prevalence of CAD and CAD severity in coronary angiography defined Chinese patients.

Methods: 2970 Chinese patients undergoing coronary angiography were enrolled. Baseline demographics and medical history data was recorded. Serum 1,5-AG levels and biochemical parameters were measured. Baseline characteristics were compared across 1,5-AG categories in diabetes (DM) and non-DM groups. Logistic regression analysis was performed to evaluate the associations of 1,5-AG with the prevalence and severity of CAD.

Results: Lower 1,5-AG was significantly associated with higher Gensini scores in both DM and non-DM groups. Logistic regression analysis demonstrated that the associations of low 1,5-AG with the prevalence of CAD, elevated Gensini score and severe CAD robustly dose-response increased from undiagnosed DM with 1,5-AG ≥ 14µg/mL to DM with 1,5-AG < 14µg/mL even after adjusting for fasting blood glucose (FBG) or Hemoglobin A1c (HbA_1c). The associations were more significant in persons with DM. Significant modification effect of DM on the relationship of 1,5-AG with elevated Gensini score was found. In addition, nonlinear relationship and threshold effects of 1,5-AG with CAD and severity were observed.

Conclusion: Low 1,5-AG is significantly and independently associated with CAD and CAD severity in Chinese patients undergoing coronary angiography. Measurement of 1,5-AG is useful to differentiate subjects with extensive glucose fluctuations and high CAD risks, especially in DM patients.

Clinical trial registration: ClinicalTrials.gov, identifier NCT03072797.

Keywords: 1,5-anhydroglucitol; coronary artery diseases; diabetes; genuine score; hemoglobin a1c.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Blood Glucose
China / epidemiology
Coronary Angiography
Coronary Artery Disease* / diagnostic imaging
Coronary Artery Disease* / epidemiology
Deoxyglucose
Glycated Hemoglobin / analysis
Humans
Prevalence
Risk Factors

Substances

Biomarkers
Blood Glucose
Glycated Hemoglobin A
1,5-anhydroglucitol
Deoxyglucose

Associated data

ClinicalTrials.gov/NCT03072797