PTFEP-Al2O3 hybrid nanowires reducing thrombosis and biofouling

Ayman Haidar; Awadelkareem A Ali; Salih Veziroglu; Jacek Fiutowski; Hermann Eichler; Isabelle Müller; Karin Kiefer; Franz Faupel; Markus Bischoff; Michael Veith; Oral Cenk Aktas; Hashim Abdul-Khaliq

doi:10.1039/c9na00436j

PTFEP-Al₂O₃ hybrid nanowires reducing thrombosis and biofouling

Nanoscale Adv. 2019 Oct 24;1(12):4659-4664. doi: 10.1039/c9na00436j. eCollection 2019 Dec 3.

Authors

Affiliations

¹ Department of Paediatric Cardiology, Saarland University Building 9 66421 Homburg Germany Hashim.Abdul-Khaliq@uks.eu.
² Chair for Multicomponent Materials, Institute for Materials Science, Faculty of Engineering, Christian-Albrechts-University of Kiel Kaiserstr. 2 24143 Kiel Germany oca@tf.uni-kiel.de.
³ Mads Clausen Institute, NanoSYD, University of Southern Denmark Alsion 2 6400 Sønderborg Denmark.
⁴ Institute of Clinical Hemostaseology and Transfusion Medicine, Saarland University Building 1, Ringstr. 52 66421 Homburg Germany.
⁵ Institute of Medical Microbiology and Hygiene, Saarland University Homburg/Saar 66421 Germany.
⁶ INM-Leibniz Institute for New Materials, Campus D2 2 Saarbrücken 66123 Germany.

Abstract

Thrombosis and bacterial infection are major problems in cardiovascular implants. Here we demonstrated that a superhydrophobic surface composed of poly(bis(2,2,2-trifluoroethoxy)phosphazene) (PTFEP)-Al₂O₃ hybrid nanowires (NWs) is effective to reduce both platelet adhesion/activation and bacterial adherence/colonization. The proposed approach allows surface modification of cardiovascular implants which have 3D complex geometries.