Combined Heart-Kidney Transplantation: Indications, Outcomes, and Controversies

Methodist Debakey Cardiovasc J. 2022 Sep 6;18(4):11-18. doi: 10.14797/mdcvj.1139. eCollection 2022.

Abstract

Renal dysfunction, a prevalent comorbidity in advanced heart failure, is associated with significant morbidity and mortality after heart transplantation. In the recent era, the field of combined heart-kidney transplantation has experienced great success in the treatment of both renal and cardiac dysfunction in end-stage disease states, and the number of transplants has increased dramatically. In this review, we discuss appropriate indications and selection criteria, overall and organ-specific outcomes, and future perspectives in the field of combined heart-kidney transplantation.

Keywords: chronic kidney disease; deceased donor kidney transplantation; heart-kidney transplantation; orthotopic heart transplantation; transplant.

Publication types

  • Review

MeSH terms

  • Heart Failure* / complications
  • Heart Failure* / diagnosis
  • Heart Failure* / surgery
  • Heart Transplantation* / adverse effects
  • Humans
  • Kidney Transplantation* / adverse effects
  • Patient Selection
  • Treatment Outcome