[Viral homologues of G-protein-coupled receptor]

C Boudry; B Costes; G Fournier; B Dewals; A Vanderplasschen

doi:10.1684/vir.2011.6294

[Viral homologues of G-protein-coupled receptor]

Virologie (Montrouge). 2007 Dec 1;11(6):457-470. doi: 10.1684/vir.2011.6294.

[Article in French]

Authors

C Boudry¹, B Costes¹, G Fournier¹, B Dewals¹, A Vanderplasschen¹

Affiliation

¹ Université de Liège, Immunologie-Vaccinologie, Faculté de médecine vétérinaire B43b, B-4000 Liège, Belgium.

PMID: 36131468
DOI: 10.1684/vir.2011.6294

Abstract

G-protein-coupled receptors (GPCR) are seven transmembrane proteins that convert extracellular stimuli to cell signaling.Viral genes homologous to cellular GPCR have been described in the genome of Betaherpesvirinae, Gammaherpesvirinae and Poxviridae. The goal of this review is to summarize the knowledge available on viral GPCR (vGPCR) with a special interest for their roles in the biology and the pathogenesis of the infection. This review highlights some properties of vGPCR that are not shared by their cellular homologues and stresses the diversity of their functions in the biology of the infection.

Keywords: GPCR; cellular G-protein-coupled receptor; vGPCR; viral G-proteincoupled receptor.

Publication types

English Abstract