Pathogenesis of Severe Liver Injury in Patients with Anorexia Nervosa: A Report of Two Cases and a Literature Review

Kurume Med J. 2022 Nov 16;67(2.3):121-129. doi: 10.2739/kurumemedj.MS6723011. Epub 2022 Sep 22.

Abstract

Anorexia nervosa (AN) can cause severe protein energy malnutrition and the consequent development of various organ disorders. AN is known to cause hepatic complications. We report two cases of starvation and refeeding-induced liver injury in patients with AN, and review the literature on the hepatic complications of AN. Acute liver injury can be induced by both starvation and refeeding, although the underlying pathomechanisms and management of liver injury differ between these two conditions. Clinicians should carefully identify the clinical features to ensure an accurate diagnosis and appropriate management of these conditions.

Keywords: anorexia nervosa; hepatic complication; refeeding syndrome; starvation induced liver injury.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Anorexia Nervosa* / complications
  • Anorexia Nervosa* / diagnosis
  • Anorexia Nervosa* / metabolism
  • Humans
  • Liver