Pd-Catalyzed Borylsilylative Cyclization of 1,6-Allenynes

Org Lett. 2022 Sep 30;24(38):7021-7025. doi: 10.1021/acs.orglett.2c02878. Epub 2022 Sep 21.

Abstract

A Pd-catalyzed borylsilylative cyclization of 1,6-allenynes with PhMe2SiBpin was developed. This method provides a practical and general method to afford the carbocycles and heterocycles bearing silyl and boryl groups with excellent regioselectivities and stereoselectivities in high to excellent yields.