Serial Changes in Troponin I in COVID-19 Vaccine-Associated Myocarditis

Jairo Aldana-Bitar; Noah R Ramirez; Allan S Jaffe; Venkat S Manubolu; Dhiran Verghese; Luay Hussein; Lauren R Anderson; Matthew J Budoff; Ronald P Karlsberg

doi:10.14740/cr1412

Serial Changes in Troponin I in COVID-19 Vaccine-Associated Myocarditis

Cardiol Res. 2022 Aug;13(4):250-254. doi: 10.14740/cr1412. Epub 2022 Aug 15.

Authors

Jairo Aldana-Bitar^{1

2}, Noah R Ramirez¹, Allan S Jaffe^{3

4}, Venkat S Manubolu², Dhiran Verghese², Luay Hussein², Lauren R Anderson¹, Matthew J Budoff², Ronald P Karlsberg^{1

5

6}

Affiliations

¹ Cardiovascular Research Foundation of Southern California, Beverly Hills, CA, USA.
² The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Los Angeles, CA, USA.
³ Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
⁴ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
⁵ Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.
⁶ David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

PMID: 36128420
PMCID: PMC9451592
DOI: 10.14740/cr1412

Abstract

A 63-year-old woman presented with atypical chest pain after a third dose of the coronavirus disease 2019 (COVID-19) messenger ribonucleic acid (mRNA) vaccine. Serial cardiac troponin measurements were performed to evaluate the trajectory of her time-concentration curve which showed a typical myocarditis curve with rapid normalization. The diagnosis of myocarditis was confirmed by cardiac magnetic resonance imaging and follow-up imaging showed resolution. All symptoms resolved with weeks.

Keywords: COVID-19; Myocarditis; Troponin curve; Vaccine.

Publication types

Case Reports