Recent applications of organic molecule-based framework porous materials in solid-phase microextraction for pharmaceutical analysis

Abstract

Sample preparation is an indispensable part of detection of complex samples in pharmaceutical analysis. Solid-phase microextraction (SPME) has obtained a lot of attention due to its advantages of time saving, less solvent and easily automation. A variety of functional materials are used as sorbents in SPME to carry out selective and high extraction. This review centers around the recent applications of organic molecule-based framework porous materials, such as metal organic frameworks (MOFs) and covalent organic frameworks (COFs), as SPME coating materials mainly focus on pharmaceutical analysis in food, environment, and biological samples. Four representative extraction devices are introduced, including on-fiber SPME, in-tube SPME, thin film SPME, stir bar SPME. The application prospect of other organic porous materials as sorbents for pharmaceutical analysis are also discussed, such as hyper crosslinked polymers (HCPs) and conjugated microporous polymers (CMPs). The progresses and discusses are provided to offer references for further research focusing on application and development of organic molecule-based framework porous materials in the field of SPME.

Keywords: Covalent organic frameworks; Metal organic frameworks; Pharmaceutical analysis; Solid-phase microextraction.