Anatomical and neurophysiological localization of the leg motor area at the medial central sulcus

Abstract

Objective: The exact location of the leg motor area is still in debate due to the lack of landmarks such as 'precentral knob' in the medial cortex. This study tried to identify the leg motor area based on intraoperative neurophysiological data and neuroimaging techniques.

Methods: Intraoperative data of somatosensory evoked potential (SEP) elicited by tibial nerve stimulation and motor evoked potential (MEP) of the leg muscles induced by direct cortical stimulation were recorded using subdural electrodes placed in the medial cortex. We displayed the neurophysiological data on the individual MR images and the MNI52.

Results: Definite N40-P40 phase reversal was observed with the shallow grooves in the medial cortex in 5 cases. Leg MEP was successfully obtained in all 12 cases preserving the leg motor function. Superimposed SEP and leg MEP data on the MNI152 indicated the leg motor area was predominantly located in the posterior two-thirds between the vertical lines passing through the anterior commissure and the posterior commissure (VCP).

Conclusions: Our study revealed the location of the leg motor area and the presence of the 'medial central sulcus' in the medial cortex.

Significance: The VCP can be useful landmark to identify the sensorimotor border in the medial cortex.

Keywords: Central sulcus; Leg motor area; Medial cortex; Motor evoked potential; Phase reversal; Somatosensory evoked potential.