Metal organic frameworks (MOFs), a class of coordination polymers, gained popularity in the late 1990s with the efforts of Omar Yaghi, Richard Robson, Susumu Kitagawa, and others. The intrinsic porosity of MOFs made them a clear platform for gas storage and separation. Indeed, these applications have dominated the vast literature in MOF synthesis, characterization, and applications. However, even in those early years, there were hints to more advanced applications in light-MOF interactions and catalysis. This perspective focuses on the combination of both light-MOF interactions and catalysis: MOF artificial photosynthetic assemblies. Light absorption, charge transport, H2O oxidation, and CO2 reduction have all been previously observed in MOFs; however, work toward a fully MOF-based approach to artificial photosynthesis remains out of reach. Discussed here are the current limitations with MOF-based approaches: diffusion through the framework, selectivity toward high value products, lack of integrated studies, and stability. These topics provide a roadmap for the future development of fully integrated MOF-based assemblies for artificial photosynthesis.