Catalyst-free synthesis of acenaphthoindolopyrimidine derivatives

Abstract

A one pot three component reaction of acenaphthoquinone, barbituric acid/thiobarbituric acid/N,N-dimethyl barbituric acid and arylamines in ethanol for the synthesis of acenaphthoindolopyrimidine derivatives is reported. The reactions take place without a catalyst and gentle conditions. This method is facile and has some benefits such as, readily available starting materials, green solvent, catalyst-free, no column chromatographic purification and good to high yields.

Keywords: Acenaphthoquinone; Arylamines; Barbituric acid; N,N-Dimethyl barbituric acid; Thiobarbituric acid.