Functions and therapeutic interventions of non-coding RNAs associated with TLR signaling pathway in atherosclerosis

Ria Margiana; Fahad Alsaikhan; Ghaidaa Raheem Lateef Al-Awsi; Indrajit Patra; Ramaswamy Sivaraman; Ali Abdulhussain Fadhil; Hawra'a Fadhel Abbas Al-Baghdady; Maytham T Qasim; Noora M Hameed; Yasser Fakri Mustafa; Seyedreza Hosseini-Fard

doi:10.1016/j.cellsig.2022.110471

Functions and therapeutic interventions of non-coding RNAs associated with TLR signaling pathway in atherosclerosis

Cell Signal. 2022 Dec:100:110471. doi: 10.1016/j.cellsig.2022.110471. Epub 2022 Sep 16.

Affiliations

¹ Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dr. Soetomo General Academic Hospital, Surabaya, Jakarta, Indonesia.
² College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia. Electronic address: fsaikhan@hotmail.com.
³ Department of Radiological Techniques, Al-Mustaqbal University College, 51001 Hillah, Babylon, Iraq.
⁴ An Independent Researcher, PhD from NIT Durgapur, Durgapur, West Bengal, India.
⁵ Dwaraka Doss Goverdhan Doss Vaishnav College, University of Madras, Arumbakkam, Chennai, India.
⁶ College of Medical Technology, Medical Lab techniques, Al-farahidi University, Iraq.
⁷ College of Dentistry, the Islamic University, Najaf, Iraq.
⁸ Department of Anesthesia, College of Health and Medical Technololgy, Al-Ayen University, Thi-Qar, Iraq.
⁹ Anesthesia techniques, Al-Nisour University College, Baghdad, Iraq.
¹⁰ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul 41001, Iraq.
¹¹ Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 36122884
DOI: 10.1016/j.cellsig.2022.110471

Abstract

Nowadays, emerging data demonstrate that the toll-like receptor (TLR) signaling pathway plays an important role in the progression of inflammatory atherosclerosis. Indeed, dysregulated TLR signaling pathway could be a cornerstone of inflammation and atherosclerosis, which contributes to the development of cardiovascular diseases. It is interesting to note that this pathway is heavily controlled by several mechanisms, such as epigenetic factors in which the role of non-coding RNAs (ncRNAs), particularly microRNAs and long noncoding RNAs as well as circular RNAs in the pathogenesis of atherosclerosis has been well studied. Recent years have seen a significant surge in the amount of research exploring the interplay between ncRNAs and TLR signaling pathway downstream targets in the development of atherosclerosis; however, there is still considerable room for improvement in this field. The current study was designed to review underlying mechanisms of TLR signaling pathway and ncRNA interactions to shed light on therapeutic implications in patients with atherosclerosis.

Keywords: Atherosclerosis; Inflammation; TLR signaling; circRNAs; lncRNA; miRNA; ncRNA.

Publication types

Review