Do neutrophil to lymphocyte ratio and platelet to lymphocyte ratio associate with frailty in elderly inpatient with comorbidity?

Exp Gerontol. 2022 Nov:169:111955. doi: 10.1016/j.exger.2022.111955. Epub 2022 Sep 16.

Abstract

Objective: Inflammation is one of the pathogenesis of frailty, Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are newly proposed inflammatory indicators. This study aimed to explore the relationship between NLR, PLR and frailty in elderly inpatient with comorbidity.

Methods: Inpatient elderly with comorbidity in our geriatric department from January 2015 to December 2018 were selected, and three groups, which included frailty, pre-frailty and robust, were divided by 5-item FRAIL scale. General data of the patients were collected, and comprehensive geriatric assessment was performed. NLR and PLR were calculated by neutrophil, lymphocyte and platelet in blood. SPSS24.0 software was used for analysis.

Results: CONCLUSION: Although results from the present study revealed associations between frailty and neutrophil and NLR in elderly inpatient with comorbidity, the potential role of these inflammation indicators on frailty needs further prospective investigation and researches involving larger population to improve its reliability.

Keywords: Elderly inpatient; Frailty; Inflammation; Neutrophil to lymphocyte ratio; Platelet to lymphocyte ratio.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Blood Platelets
  • Comorbidity
  • Frailty*
  • Humans
  • Inflammation
  • Inpatients
  • Lymphocyte Count
  • Lymphocytes
  • Neutrophils*
  • Platelet Count
  • Reproducibility of Results
  • Retrospective Studies