The role and regulatory mechanism of m6A methylation in the nervous system

Lingling Jiang; Xiaoheng Li; Shasha Wang; Zengqiang Yuan; Jinbo Cheng

doi:10.3389/fgene.2022.962774

The role and regulatory mechanism of m⁶A methylation in the nervous system

Front Genet. 2022 Sep 1:13:962774. doi: 10.3389/fgene.2022.962774. eCollection 2022.

Authors

Lingling Jiang^{1

2}, Xiaoheng Li², Shasha Wang^{1

2}, Zengqiang Yuan², Jinbo Cheng^{2

3}

Affiliations

¹ Hengyang Medical College, University of South China, Hengyang, China.
² The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China.
³ Center on Translational Neuroscience, College of Life & Environmental Science, Minzu University of China, Beijing, China.

Abstract

N6-methyladenosine (m⁶A) modification regulates RNA translation, splicing, transport, localization, and stability at the post-transcriptional level. The m⁶A modification has been reported to have a wide range of effects on the nervous system, including neurogenesis, cerebellar development, learning, cognition, and memory, as well as the occurrence and development of neurological disorders. In this review, we aim to summarize the findings on the role and regulatory mechanism of m⁶A modification in the nervous system, to reveal the molecular mechanisms of neurodevelopmental processes, and to promote targeted therapy for nervous system-related diseases.

Keywords: development; m6A methylation; mechanism; nervous system; neurological disorders.

Publication types

Review