Panax japonicus and chikusetsusaponins: A review of diverse biological activities and pharmacology mechanism

Xiao-Juan Wang; Qian Xie; Yang Liu; Sai Jiang; Wei Li; Bin Li; Wei Wang; Chang-Xiao Liu

doi:10.1016/j.chmed.2020.12.003

Panax japonicus and chikusetsusaponins: A review of diverse biological activities and pharmacology mechanism

Chin Herb Med. 2020 Dec 8;13(1):64-77. doi: 10.1016/j.chmed.2020.12.003. eCollection 2021 Jan.

Authors

Xiao-Juan Wang¹, Qian Xie², Yang Liu², Sai Jiang², Wei Li², Bin Li², Wei Wang², Chang-Xiao Liu³

Affiliations

¹ Hunan Food and Drug Vocational College, Changsha 410208, China.
² TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Drug Research Institute, Sino-Pakistan TCM & Ethnomedicine Research International Cooperation Base (Hunan Province), School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
³ Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China.

Abstract

Panax japonicus, which in the Tujia dialect is known as "Baisan Qi" and "Zhujieshen", is a classic "qi" drug of Tujia ethnomedicine and it has unique effects on disease caused by "qi" stagnation and blood stasis. This paper serves as the basis of further scientific research and development of Panax japonicus. The pharmacology effects of molecular pharmacology were discussed and summarized. P. japonicus plays an important role on several diseases, such as rheumatic arthritis, cancer, cardiovascular agents, and this review provides new insights into P. japonicus as promising agents to substitute ginseng and notoginseng.

Keywords: Panax ginseng C. A. Mey; Panax japonicas (T. Nees) C. A. Meyer; Panax notoginseng (Burk.) F. H. Chen; chikusetsusaponin; ginsenoside.

Publication types

Review