Ten new prenylated flavonoids from Macaranga denticulata and their antitumor activities

Jia-Bi Huang; Yuan-Si Chen; Meng-Ru Wang; Rong-Shuai Li; Xue-Rong Zhao; Joseph Sakah Kaunda; Rui-Han Zhang; Xing-Jie Zhang; Wei-Lie Xiao; Hong-Liang Li; Xiao-Li Li

doi:10.1016/j.fitote.2022.105302

Ten new prenylated flavonoids from Macaranga denticulata and their antitumor activities

Fitoterapia. 2022 Oct:162:105302. doi: 10.1016/j.fitote.2022.105302. Epub 2022 Sep 16.

Authors

Affiliations

¹ Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming 650500, PR China.
² Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming 650500, PR China; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650091, PR China.
³ Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming 650500, PR China. Electronic address: lihongliang@ynu.edu.cn.
⁴ Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming 650500, PR China. Electronic address: lixiaoli@ynu.edu.cn.

PMID: 36116613
DOI: 10.1016/j.fitote.2022.105302

Abstract

Ten new prenylated flavonoids, named denticulains A-J (1-10), together with seven known prenylated flavonoids (11-17) were isolated from Macaranga denticulata. Their structures were elucidated on the basis of detailed spectroscopic analysis and by comparison with literature data. In addition, compounds 1 and 14 inhibited the proliferation of SW620 and HCT-116 cell lines with an IC₅₀ value of 46.08 μM and 56.83 μM, respectively.

Keywords: Antitumor activity; Macaranga denticulata; Prenylated flavonoids.

MeSH terms

Antineoplastic Agents, Phytogenic* / chemistry
Antineoplastic Agents, Phytogenic* / pharmacology
Drug Screening Assays, Antitumor
Euphorbiaceae* / chemistry
Flavonoids / chemistry
Flavonoids / pharmacology
Molecular Structure

Substances

Antineoplastic Agents, Phytogenic
Flavonoids