Magnetic nanocomposites for biomedical applications

Mina Naghdi; Mahsa Ghovvati; Navid Rabiee; Sepideh Ahmadi; Nikzad Abbariki; Soheil Sojdeh; Amirhossein Ojaghi; Mojtaba Bagherzadeh; Omid Akhavan; Esmaeel Sharifi; Mohammad Rabiee; Mohammad Reza Saeb; Keivan Bolouri; Thomas J Webster; Ehsan Nazarzadeh Zare; Ali Zarrabi

doi:10.1016/j.cis.2022.102771

Magnetic nanocomposites for biomedical applications

Adv Colloid Interface Sci. 2022 Oct:308:102771. doi: 10.1016/j.cis.2022.102771. Epub 2022 Sep 7.

Authors

Mina Naghdi¹, Mahsa Ghovvati², Navid Rabiee³, Sepideh Ahmadi⁴, Nikzad Abbariki⁵, Soheil Sojdeh⁶, Amirhossein Ojaghi⁵, Mojtaba Bagherzadeh⁵, Omid Akhavan⁷, Esmaeel Sharifi⁸, Mohammad Rabiee⁹, Mohammad Reza Saeb¹⁰, Keivan Bolouri², Thomas J Webster¹¹, Ehsan Nazarzadeh Zare¹², Ali Zarrabi¹³

Affiliations

¹ Department of Chemistry, Isfahan University of Technology, 84156-83111 Isfahan, Iran.
² Department of Radiological Sciences, David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA 90095, USA.
³ School of Engineering, Macquarie University, Sydney, New South Wales 2109, Australia; Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran; Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, South Korea. Electronic address: nrabiee94@gmail.com.
⁴ Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran 19857-17443, Iran; Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran 19857-17443, Iran.
⁵ Department of Chemistry, Sharif University of Technology, Tehran, Iran.
⁶ School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
⁷ Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran.
⁸ Institute for Polymers, Composites and Biomaterials, National Research Council (IPCB-CNR), Naples 80125, Italy.
⁹ Biomaterial Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
¹⁰ Department of Polymer Technology, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza 11/12, 80-233 Gdańsk, Poland.
¹¹ School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, China.
¹² School of Chemistry, Damghan University, Damghan 36716-41167, Iran. Electronic address: ehsan.nazarzadehzare@gmail.com.
¹³ Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul 34396, Turkey.

PMID: 36113311
DOI: 10.1016/j.cis.2022.102771

Abstract

Tissue engineering and regenerative medicine have solved numerous problems related to the repair and regeneration of damaged organs and tissues arising from aging, illnesses, and injuries. Nanotechnology has further aided tissue regeneration science and has provided outstanding opportunities to help disease diagnosis as well as treat damaged tissues. Based on the most recent findings, magnetic nanostructures (MNSs), in particular, have emerged as promising materials for detecting, directing, and supporting tissue regeneration. There have been many reports concerning the role of these nano-building blocks in the regeneration of both soft and hard tissues, but the subject has not been extensively reviewed. Here, we review, classify, and discuss various synthesis strategies for novel MNSs used in medicine. Advanced applications of magnetic nanocomposites (MG-NCs), specifically magnetic nanostructures, are further systematically reviewed. In addition, the scientific and technical aspects of MG-NC used in medicine are discussed considering the requirements for the field. In summary, this review highlights the numerous opportunities and challenges associated with the use of MG-NCs as smart nanocomposites (NCs) in tissue engineering and regenerative medicine.

Keywords: Biomaterials; Cell labeling; Cytocompatibility; Magnetic nanocomposites; Scaffolds; Stem cells.

Publication types

Review

MeSH terms

Biocompatible Materials / chemistry
Magnetic Phenomena
Nanocomposites* / chemistry
Nanotechnology
Regenerative Medicine
Tissue Engineering*

Substances

Biocompatible Materials