Abstract
Chhetri and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202112073) show that Rab11-mediated endosomal recycling regulates cell surface expression of McLeod syndrome protein XK. Mutant huntingtin interferes with the recycling of XK to the cell surface and significantly reduces manganese transport across cell membrane.
© 2022 Marsan and Huang.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Comment
MeSH terms
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Amino Acid Transport Systems, Neutral* / metabolism
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Cell Membrane / metabolism
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Endosomes* / metabolism
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Humans
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Huntington Disease* / complications
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Manganese* / metabolism
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Neuroacanthocytosis* / complications
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rab GTP-Binding Proteins / metabolism
Substances
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Amino Acid Transport Systems, Neutral
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XK protein, human
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Manganese
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rab11 protein
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rab GTP-Binding Proteins
Supplementary concepts
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Neuroacanthocytosis, Mcleod Type