Comparative Study of the Efficacy of Advanced Platelet-rich Fibrin and Standard Platelet-rich Fibrin in Mandibular Third Molar Surgery

Rahim Riaz; Mensudar Radhakrishnan; Jayavelu Perumal

doi:10.4103/jpbs.jpbs_157_22

Comparative Study of the Efficacy of Advanced Platelet-rich Fibrin and Standard Platelet-rich Fibrin in Mandibular Third Molar Surgery

J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S781-S787. doi: 10.4103/jpbs.jpbs_157_22. Epub 2022 Jul 13.

Authors

Rahim Riaz¹, Mensudar Radhakrishnan², Jayavelu Perumal³

Affiliations

¹ Department of Oral and Maxillofacial Surgery, Research Scholar, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
² Department of Conservative Dentistry, Sri Balaji Dental College and Hospital, Chennai, Tamil Nadu, India.
³ Department of OMFS, Madha Dental College, Chennai, Tamil Nadu, India.

Abstract

Background: Disimpaction of mandibular of third molar is one of the commonest minor oral surgical procedures. Platelet-rich fibrin (PRF) plays a vital role in both hard and soft tissue healing. There are various subtypes of PRF used for different surgical sites.

Objective: The purpose of this study is to compare and evaluate the effectiveness of Advanced PRF (A-PRF) and Standard PRF (S-PRF) in the healing process of the surgical sites after the removal of mandibular third molars. Changes in swelling, pain, and mouth opening were evaluated.

Materials and methods: 10 patients (3 men, 7 women; 18-35 years old) were selected for the removal of bilateral impacted mandibular third molar teeth. A-PRF and S-PRF were placed in the right-hand side for 5 patients in each group. In both the groups, the left side of the patients was taken as the control group. Postoperative pain was measured using a visual analogue scale (VAS), postoperative swelling was calculated using the distance between multiple facial landmarks (method) and mouth opening measured interincisally on the 1^st postoperative day, 3^rd day, and the 7^th day, respectively. SPSS version 26.0 was used for data analysis.

Results: Advanced PRF group recorded noteworthy improvement in pain (P = 0.063), swelling (P = 0.001), and mouth opening (P = 0.013) when compared to the standard PRF group. There was statistically substantial variance between the advanced PRF and standard PRF groups.

Conclusion: Advanced PRF group showed decreased swelling, pain, and increased mouth opening compared to standard PRF group.

Keywords: A-PRF; PRF; S-PRF; impacted third molar surgery; mouth opening; pain; swelling.