Significance of HOXD transcription factors family in progression, migration and angiogenesis of cancer

Lumin Wang; Chenyang Qiao; Li Cao; Shuang Cai; Xiaoping Ma; Xinqiu Song; Qiuyu Jiang; Chen Huang; Jinhai Wang

doi:10.1016/j.critrevonc.2022.103809

Significance of HOXD transcription factors family in progression, migration and angiogenesis of cancer

Crit Rev Oncol Hematol. 2022 Nov:179:103809. doi: 10.1016/j.critrevonc.2022.103809. Epub 2022 Sep 13.

Authors

Lumin Wang¹, Chenyang Qiao², Li Cao³, Shuang Cai³, Xiaoping Ma³, Xinqiu Song⁴, Qiuyu Jiang³, Chen Huang⁵, Jinhai Wang⁶

Affiliations

¹ Gastroenterology department, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China; Institute of precision medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
² Gastroenterology department, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
³ Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, PR China.
⁴ Department of Cell Biology and Genetics, Medical College of Yan'an University, Yan'an, Shaanxi, PR China.
⁵ Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, PR China; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, PR China. Electronic address: hchen@xjtu.edu.cn.
⁶ Gastroenterology department, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China; Institute of precision medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China. Electronic address: jinhaiwang@hotmail.com.

PMID: 36108961
DOI: 10.1016/j.critrevonc.2022.103809

Abstract

The transcription factors (TFs) of the HOX family play significant roles during early embryonic development and cellular processes. They also play a key role in tumorigenesis as tumor oncogenes or suppressors. Furthermore, TFs of the HOXD geFIne cluster affect proliferation, migration, and invasion of tumors. Consequently, dysregulated activity of HOXD TFs has been linked to clinicopathological characteristics of cancer. HOXD TFs are regulated by non-coding RNAs and methylation of DNA on promoter and enhancer regions. In addition, HOXD genes modulate the biological function of cancer cells via the MEK and AKT signaling pathways, thus, making HOXD TFs, a suitable molecular marker for cancer prognosis and therapy. In this review, we summarized the roles of HOXD TFs in different cancers and highlighted its potential as a diagnostic and therapeutic target.

Keywords: HOXD; Molecular markers; Signaling pathway; Therapeutic target; Transcription factors; Tumorigenesis.

Publication types

Review

MeSH terms

Cell Line, Tumor
Cell Proliferation / genetics
Gene Expression Regulation, Neoplastic
Humans
Mitogen-Activated Protein Kinase Kinases
Neoplasms* / diagnosis
Neoplasms* / genetics
Proto-Oncogene Proteins c-akt / metabolism
RNA, Long Noncoding* / genetics
Transcription Factors / genetics

Substances

RNA, Long Noncoding
Transcription Factors
Proto-Oncogene Proteins c-akt
Mitogen-Activated Protein Kinase Kinases