Successful salvage surgery of the residual tumor after boron neutron capture therapy (BNCT): A case report

Masaaki Higashino; Teruhito Aihara; Akiko Ozaki; Naonori Hu; Kayako Isohashi; Koji Ono; Keiji Nihei; Yoshitaka Kurisu; Ryo Kawata

doi:10.1016/j.apradiso.2022.110420

Successful salvage surgery of the residual tumor after boron neutron capture therapy (BNCT): A case report

Appl Radiat Isot. 2022 Nov:189:110420. doi: 10.1016/j.apradiso.2022.110420. Epub 2022 Aug 18.

Authors

Masaaki Higashino¹, Teruhito Aihara², Akiko Ozaki³, Naonori Hu⁴, Kayako Isohashi⁴, Koji Ono⁴, Keiji Nihei⁵, Yoshitaka Kurisu⁶, Ryo Kawata³

Affiliations

¹ Department of Otorhinolaryngology, Head and Neck Surgery, Osaka Medical and Pharmaceutical University, Japan. Electronic address: masaaki.higashino@ompu.ac.jp.
² Department of Otorhinolaryngology, Head and Neck Surgery, Osaka Medical and Pharmaceutical University, Japan; Kansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, Japan.
³ Department of Otorhinolaryngology, Head and Neck Surgery, Osaka Medical and Pharmaceutical University, Japan.
⁴ Kansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, Japan.
⁵ Kansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, Japan; Department of Radiation Oncology, Osaka Medical and Pharmaceutical University, Japan.
⁶ Department of Pathology, Osaka Medical and Pharmaceutical University, Japan.

PMID: 36108532
DOI: 10.1016/j.apradiso.2022.110420

Abstract

Salvage surgery after radiation therapy is known to be associated with a high incidence of postoperative complications. We describe a case of a successful salvage surgery after BNCT. In our patient with head and neck carcinoma, cervical lymph node recurrence with adhesion to a large vessel occurred after conventional radiotherapy. This lesion responded well to BNCT. Salvage surgery was subsequently performed to remove the residual tumor. Histopathologically, the isolated tissue contained tumor cells in its center and the surrounding tissue showed severe fibrosis. However, the tissue outside of the irradiation area had almost no fibrosis. BNCT may facilitate salvage surgery after radiotherapy because it causes less injury to the surrounding tissue than conventional radiotherapy. Our experience suggests that BNCT may be a feasible preoperative treatment in patients with inoperable lesions or in those who strongly desire preservation of function.

Keywords: BNCT; Cervical node metastasis; Head and neck carcinoma; Recurrence; Salvage surgery.

Publication types

Case Reports

MeSH terms

Boron Compounds
Boron Neutron Capture Therapy* / methods
Head and Neck Neoplasms* / radiotherapy
Humans
Neoplasm Recurrence, Local / radiotherapy
Neoplasm, Residual / radiotherapy
Salvage Therapy

Substances

Boron Compounds