A multifunctional Fe2O3@MoS2@SDS Z-scheme nanocomposite: NIR enhanced bacterial inactivation, degradation antibiotics and inhibiting ARGs dissemination

Honggui Wang; Xinhao Li; Qingfeng Ge; Yang Chong; Ya Zhang

doi:10.1016/j.colsurfb.2022.112833

A multifunctional Fe₂O₃@MoS₂@SDS Z-scheme nanocomposite: NIR enhanced bacterial inactivation, degradation antibiotics and inhibiting ARGs dissemination

Colloids Surf B Biointerfaces. 2022 Nov:219:112833. doi: 10.1016/j.colsurfb.2022.112833. Epub 2022 Sep 9.

Authors

Honggui Wang¹, Xinhao Li¹, Qingfeng Ge², Yang Chong³, Ya Zhang⁴

Affiliations

¹ School of Environmental Science and Engineering, Yangzhou University, 225127 Yangzhou, Jiangsu, PR China.
² School of Food Science and Technology, Yangzhou University, 225127 Yangzhou, Jiangsu, PR China.
³ Department of Traditional Chinese Medicine, The Affiliated Hospital of Yangzhou University, 225000 Yangzhou, Jiangsu, PR China. Electronic address: 092016@yzu.edu.cn.
⁴ School of Environmental Science and Engineering, Yangzhou University, 225127 Yangzhou, Jiangsu, PR China. Electronic address: zhangya@yzu.edu.cn.

PMID: 36108363
DOI: 10.1016/j.colsurfb.2022.112833

Abstract

To fight the flourishment of drug-resistant bacteria caused by antibiotics and the dissemination of antibiotic resistance genes (ARGs), it is of great urgency to develop multifunctional non-antibiotic agents with residual antibiotics elimination, and ARGs dissemination inhibition properties. Herein, sodium dodecyl sulfate (SDS) was modified onto the surface of Fe₂O₃ @MoS₂ by ultrasonic method to obtain the Z-scheme, multifunctional Fe₂O₃ @MoS₂ @SDS nanocomposites. The Fe₂O₃ @MoS₂ @SDS (weight ratio of Fe₂O₃ @MoS₂ and SDS was 1:1) was selected as the optimal agent. Under NIR irradiation, the Fe₂O₃ @MoS₂ @SDS had a photothermal conversion efficiency of 45.96%, and could generate plenty of reactive oxygen species (ROS) at the same time. Under the synergy of photothermal and photodynamic, the antibacterial efficiency of Fe₂O₃ @MoS₂ @SDS to E. coli, MRSA and P. aeruginosa could reach 99.95%, 99.97% and 99.58%, respectively, indicating excellent photothermal-photodynamic therapy (PPT) effect. The Fe₂O₃ @MoS₂ @SDS also displayed photocatalytic activity in degradation of tetracycline (TC). The degradation rate of TC could reach 92.3% after 2 h of visible light irradiation. The obtained results indicated that a promising Fe₂O₃ @MoS₂ @SDS composite based multifunctional nanoplatform could be constructed for NIR induced bacterial inactivation, antibiotics degradation and ARGs dissemination inhibition.

Keywords: Antibiotic resistance genes (ARGs); Fe(2)O(3) @MoS(2) @SDS; Near-infrared (NIR); Photothermal-photodynamic therapy (PPT); Tetracycline (TC).