Investigation of severe acute respiratory syndrome coronavirus 2 antibodies among the paediatric population in Mogadishu, Somalia

Trans R Soc Trop Med Hyg. 2023 Feb 1;117(2):139-146. doi: 10.1093/trstmh/trac088.

Abstract

Background: We undertook this cross-sectional study to determine the level of circulating anti-severe acute respiratory syndrome coronavirus 2 immunoglobulins (IgM and IgG) in children, as well as to evaluate other potential risk factors.

Methods: Children attending the outpatient department of the SOS and Benadir Hospitals in Mogadishu from 26 July to 8 August 2021 were selected following parental consent. The children (aged <18 y) were screened using the coronavirus disease 2019 (COVID-19) rapid test lateral flow immune-assay kit.

Results: Of the 500 children screened for COVID-19, 32 (6.4%) tested positive, out of which 26 (5.2%) had IgG antibodies, while five (1%) had IgM, with the other child (0.2%) having both circulating IgG and IgM antibodies. Also, 46.9% of the COVID-19-positive children were asymptomatic without any clinical signs of the disease. Children aged >6 y and those attending school were the most affected (p=0.002). The most common clinical features among positive children were fever (22.6%), cough (22.2%), shortness of breath (5.8%) and loss of smell (2.6%) and taste (2.2%). Similarly, not wearing a facemask as a preventive measure was found to be a significant risk factor (p=0.007).

Conclusions: This study shows that children are at risk of contracting COVID-19 infection. Our study also shows evidence of a high rate of IgG antibodies in school-aged children having close contact with infected adults, in those not wearing facemasks, as well as in those with a family history of comorbidities.

Keywords: COVID‐19; Somalia; comorbidity; paediatric infection; public health; sociodemographic factors.

MeSH terms

  • Adult
  • Antibodies, Viral
  • COVID-19* / epidemiology
  • Child
  • Cross-Sectional Studies
  • Humans
  • Immunoglobulin G
  • Immunoglobulin M
  • SARS-CoV-2
  • Somalia

Substances

  • Antibodies, Viral
  • Immunoglobulin G
  • Immunoglobulin M