The Relationship of Low-Density-Lipoprotein to Lymphocyte Ratio with Chronic Obstructive Pulmonary Disease

Yiben Huang; Keke Ding; Zicong Dai; Jianing Wang; Binbin Hu; Xianjing Chen; Yage Xu; Beibei Yu; Lingzhi Huang; Chunyan Liu; Xiaodiao Zhang

doi:10.2147/COPD.S369161

The Relationship of Low-Density-Lipoprotein to Lymphocyte Ratio with Chronic Obstructive Pulmonary Disease

Int J Chron Obstruct Pulmon Dis. 2022 Sep 8:17:2175-2185. doi: 10.2147/COPD.S369161. eCollection 2022.

Authors

Yiben Huang^#¹, Keke Ding^#², Zicong Dai^#², Jianing Wang², Binbin Hu², Xianjing Chen¹, Yage Xu¹, Beibei Yu¹, Lingzhi Huang¹, Chunyan Liu¹, Xiaodiao Zhang¹

Affiliations

¹ Department of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
² School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, People's Republic of China.

^# Contributed equally.

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) has been a concern all over the world because of its high prevalence and mortality. The ratio of low-density-lipoprotein to lymphocyte (LLR) has been widely used to predict the prognosis of cerebral infarction, but its association with COPD is less known. We aim to explore the relationship between LLR and COPD and to investigate its indicative role in the severity and prognosis of COPD.

Methods: In this study, 279 participants (n = 138 with COPD and n = 138 age- and sex-matched health control) were recruited. COPD patients were divided into two groups according to the optimal cut-off value of LLR determined by the receiver operating characteristic curve (ROC). We collected the clinical characteristics, pulmonary function, LLR, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and other data of all subjects. t-test, Pearson correlation test, logistic regression analysis and other statistical analysis were carried out.

Results: Compared with the healthy control group, COPD patients had a significantly higher LLR level (p < 0.001). The disease was more serious in the high LLR group, which was reflected by Global Initiative for Chronic Obstructive Lung Disease (GOLD) and BMI, airway obstruction, dyspnoea, severe exacerbations (BODE) index and St. George's Respiratory Questionnaire (SGRQ) index (p = 0.001, p = 0.013, p = 0.011, respectively). The forced expiration volume in 1 second (FEV₁) (p = 0.033) and forced expiratory volume in 1 second in percent of the predicted value (FEV₁%) (p = 0.009) in high LLR group were lower. Univariate and multivariate logistic regression analysis showed that LLR was an independent factor affecting the severity of COPD patients (odds ratio [OR] = 2.599, 95% CI: 1.266-5.337, p = 0.009).

Conclusion: We found that LLR is a novel biomarker in predicting the severity of patients with COPD. Further studies with larger database were recommended to verify our findings.

Keywords: COPD; biomarker; low-density-lipoprotein; lymphocyte.

MeSH terms

Forced Expiratory Volume
Humans
Lipoproteins, LDL
Lung
Lymphocytes
Pulmonary Disease, Chronic Obstructive*

Substances

Lipoproteins, LDL

Grants and funding

The present study was supported by the Wenzhou Municipal Sci-Tech Bureau Program (Y20210842). The Funding body had no role in the study design, data collection, analysis, interpretation of data or writing of the manuscript.