Foreign body-type giant cell reaction with extensive granulation tissue and intense inflammation after chemotherapy mimicking residual lymphoma on FDG PET

Sakib Kazi; Stavros Raptis; Farzad Abbaspour; Wanzhen Zeng

doi:10.1186/s41824-022-00137-2

Foreign body-type giant cell reaction with extensive granulation tissue and intense inflammation after chemotherapy mimicking residual lymphoma on FDG PET

Eur J Hybrid Imaging. 2022 Sep 15;6(1):18. doi: 10.1186/s41824-022-00137-2.

Authors

Sakib Kazi¹, Stavros Raptis², Farzad Abbaspour³, Wanzhen Zeng^{4

5}

Affiliations

¹ Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
² Department of Pathology and Laboratory Medicine, Montfort Hospital, Ottawa, ON, Canada.
³ Department of Nuclear Medicine, The Ottawa Hospital, Ottawa, ON, Canada.
⁴ Department of Nuclear Medicine, The Ottawa Hospital, Ottawa, ON, Canada. Wzeng@toh.ca.
⁵ Division of Nuclear Medicine, Department of Medicine, Ottawa Hospital, 1053 Carling Ave., Ottawa, ON, K1Y 4E9, Canada. Wzeng@toh.ca.

Abstract

Foreign body-type giant cell reaction is typically a biological and immunological reaction to the presence of foreign bodies such as catheters, parasites or biomaterials with a collection of fused macrophages (giant cell). We reported an unusual case of [¹⁸F]FDG PET findings in diffuse large B cell lymphoma in the urinary bladder following incomplete resection and chemotherapy. As the restaging [¹⁸F]FDG PET showed intense [¹⁸F]FDG uptake in the urinary bladder at the resection site concerning for recurrence, the lesion was subsequently resected and histopathology showed extensive granulation tissue with foreign body-type giant cell reaction with no suspected foreign bodies or neoplasia.

Keywords: Diffuse large B cell lymphoma; Foreign body-type giant cell reaction; [18F]FDG PET.