COVID-19-induced multisystem inflammatory syndrome in a child with Wilson disease: a case report

Tawhida Yassin Abdel-Ghaffar; Haidy Mohammed Zakaria; Eman Mohamed Elsayed; Sondos Magdy; Suzan El Naghi; Suhaib Alsayed Mohammed Naeem; Mahmoud Yosry Hasan; Rabab Qasim Khallaf

doi:10.1186/s43066-022-00214-y

COVID-19-induced multisystem inflammatory syndrome in a child with Wilson disease: a case report

Egypt Liver J. 2022;12(1):51. doi: 10.1186/s43066-022-00214-y. Epub 2022 Sep 9.

Authors

Tawhida Yassin Abdel-Ghaffar^{1

2}, Haidy Mohammed Zakaria^{1

3}, Eman Mohamed Elsayed^{1

4}, Sondos Magdy^{1

5}, Suzan El Naghi^{1

6}, Suhaib Alsayed Mohammed Naeem^{1

7}, Mahmoud Yosry Hasan^{1

5}, Rabab Qasim Khallaf^{1

8}

Affiliations

¹ Dr. Yassin Abdel Ghaffar Charity Center for Liver Disease and Research, 6 Emarat El Tasnieea St. from Makram Ebeid, Nasr City, Cairo 11566 Egypt.
² Department of Pediatrics, Pediatric Hepatology, Faculty of Medicine, Ain Shams University, Cairo, 11591 Egypt.
³ Department of Clinical Research and Health Development, Menoufia Directorate of Health Affairs, Ministry of Health and Population, Shebin El-Kom, Menoufia 32511 Egypt.
⁴ Department of Pediatrics, Pediatric Cardiology, Faculty of Medicine, Ain Shams University, Cairo, 11591 Egypt.
⁵ Department of Pediatrics, Pediatric Intensive Care, Faculty of Medicine, Ain Shams University, Cairo, 11591 Egypt.
⁶ Department of Pediatrics, National Hepatology and Tropical Medicine Research Institute (NHTMRI), Cairo, Egypt.
⁷ Department of Histology, Faculty of Medicine, Al-Azhar University, Cairo, 71524 Egypt.
⁸ Department of Pediatrics, El-Shohda Central Hospital, Ministry of Health and Population, El-Shohda, Menoufia 32841 Egypt.

Abstract

Background: Infection with coronavirus disease 2019 (COVID-19) can progress to the multisystem inflammatory syndrome in children (MIS-C). Patients with liver cirrhosis are at increased risk of complications.

Case presentation: We report on a 13-year-old Wilson's disease patient who was referred for liver transplantation because of rapid deterioration in his hepatic condition. After admission, he developed fever, respiratory distress, coronary arteries dilatation on echocardiography, laboratory evidence of inflammation, and positive severe acute respiratory syndrome coronavirus (SARS-CoV-2) PCR. SARS-CoV-2-induced MIS-C was diagnosed. Inspite of aggressive management of MIS-C, progressive deterioration of the respiratory, liver, kidney, and cardiac functions occurred and he passed away.

Conclusion: MIS-C is a serious possible complication leading to multiorgan failure and higher death rate especially in cirrhotic children. So, early diagnosis and management with higher level of care by a multidisciplinary team are warranted.

Keywords: COVID-19; MIS-C; Multiorgan failure; Wilson’s disease.

Publication types

Case Reports