COVID-19 and Diabetes Mellitus: Mutual Interplay of Two Diseases

Patrik Krumpolec; Dominik Kodada; Nikola Nyáriová; Vanda Repiská; Gabriel Minárik

doi:10.2174/1573399819666220913113146

COVID-19 and Diabetes Mellitus: Mutual Interplay of Two Diseases

Curr Diabetes Rev. 2023;19(9):e130922208761. doi: 10.2174/1573399819666220913113146.

Authors

Patrik Krumpolec¹, Dominik Kodada^{1

2}, Nikola Nyáriová^{1

2}, Vanda Repiská², Gabriel Minárik¹

Affiliations

¹ Medirex Group Academy n.p.o., Novozamocka 67, Nitra, Slovakia.
² Faculty of Medicine, Department of Clinical Biology, Genetics and Clinical Genetics, Comenius University in Bratislava, Sasinkova 4, Bratislava, Slovakia.

PMID: 36100987
DOI: 10.2174/1573399819666220913113146

Abstract

Currently, when the world is fighting against the rapidly spreading pandemic of COVID-19, the silent epidemic of diabetes should not be set aside. In comparison, while COVID- 19 led to about 6 million deaths in 2021, diabetes caused 6.7 million deaths in the same year. Diabetes mellitus is a serious risk factor for worse outcomes in COVID-19 patients. Moreover, it seems that there is a bidirectional relationship between pre-existing diabetes pandemic and the rapidly spreading COVID-19 pandemic. In this article, we summarize mechanisms by which SARS-CoV-2 infects the host cell and discuss the bidirectional relationship between diabetes and COVID-19. We also focus on clinical variables in which diabetic patients differ from non-diabetic patients and which could have promising predictive value for the course and outcome of diabetic COVID-19 patients' therapy management.

Keywords: Angiotensin-Converting Enzyme 2; COVID-19; diabetes; diabetes mellitus; immunity; inflammation.

MeSH terms

COVID-19* / complications
Diabetes Mellitus* / epidemiology
Humans
Pandemics
Peptidyl-Dipeptidase A
SARS-CoV-2

Substances

Peptidyl-Dipeptidase A