Colorectal cancer: Metabolic interactions reshape the tumor microenvironment

Jiawei Chen; Haodong Zhu; Yuhang Yin; Siyuan Jia; Xiangjian Luo

doi:10.1016/j.bbcan.2022.188797

Colorectal cancer: Metabolic interactions reshape the tumor microenvironment

Biochim Biophys Acta Rev Cancer. 2022 Sep;1877(5):188797. doi: 10.1016/j.bbcan.2022.188797. Epub 2022 Sep 11.

Authors

Jiawei Chen¹, Haodong Zhu¹, Yuhang Yin¹, Siyuan Jia¹, Xiangjian Luo²

Affiliations

¹ Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078, PR China; Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan 410078, PR China.
² Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078, PR China; Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan 410078, PR China; Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, China; Key Laboratory of Biological Nanotechnology of National Health Commission, Central South University, Changsha, Hunan 410078, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410078, China. Electronic address: luocsu@csu.edu.cn.

PMID: 36100193
DOI: 10.1016/j.bbcan.2022.188797

Abstract

Colorectal cancer (CRC) is one of the most common cancers worldwide, which ranks third in terms of incidence and the second leading cause of cancer-related mortality. Metabolic reprogramming within the tumor microenvironment (TME) has been proved intimately involved in the initiation and malignant progression of CRC. Signal messengers, including cytokines, metabolites, and exosomes among others, derived from cancer cells can be utilized by the surrounding cells within the TME to induce metabolic alteration and cancer-associated transformation. In turn, the cargos secreted from cancer-associate cells further provide the nutrition and energy supply for cancer cells, supporting their metabolic reprogramming to promote proliferation, migration, metastasis, and radiochemoresistance. In this review, we focus on the main cellular components in the TME: CAFs, TAMs, lymphocytes and neutrophils, and enumerate and integrate how the metabolic interactions between these components and cancer cells reshape TME to foster CRC malignancy.

Keywords: Colorectal cancer; Metabolic reprogramming; Tumor microenvironment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Colorectal Neoplasms* / pathology
Cytokines / metabolism
Exosomes* / metabolism
Humans
Tumor Microenvironment

Substances

Cytokines