Dual-Energy Computed Tomography as an Adjunct in the Evaluation of Peripheral Chronic Total Occlusions: A Feasibility Study

Nikolas Matthaiou; Nikolaos Galanakis; Antonios E Papadakis; Elias Kehagias; Nikolaos Kontopodis; Stavros Charalambous; Konstantinos Perisinakis; Thomas G Maris; Christos V Ioannou; Dimitrios Tsetis

doi:10.1016/j.jvir.2022.09.006

Dual-Energy Computed Tomography as an Adjunct in the Evaluation of Peripheral Chronic Total Occlusions: A Feasibility Study

J Vasc Interv Radiol. 2022 Dec;33(12):1531-1535. doi: 10.1016/j.jvir.2022.09.006. Epub 2022 Sep 11.

Affiliations

¹ Interventional Radiology Unit, Department of Medical Imaging, University Hospital Heraklion, Heraklion, Greece; Department of Radiology, University of Crete Medical School, Heraklion, Greece.
² Interventional Radiology Unit, Department of Medical Imaging, University Hospital Heraklion, Heraklion, Greece.
³ Department of Medical Physics, University Hospital Heraklion, University of Crete Medical School, Heraklion, Greece.
⁴ Vascular Surgery Unit, Department of Cardiothoracic and Vascular Surgery, University Hospital Heraklion, University of Crete Medical School, Heraklion, Greece.
⁵ Interventional Radiology Unit, Department of Medical Imaging, University Hospital Heraklion, Heraklion, Greece; Department of Radiology, University of Crete Medical School, Heraklion, Greece. Electronic address: tsetisd@uoc.gr.

PMID: 36100065
DOI: 10.1016/j.jvir.2022.09.006

Abstract

This study investigated the role of dual-energy computed tomography (CT) for lesion characterization in patients with peripheral arterial disease manifesting with chronic total occlusions (CTOs). Forty-one symptomatic patients with CTOs underwent dual-energy CT angiography before endovascular treatment. The lesions were subsequently analyzed in a dedicated workstation, and 2 indexes-dual-energy index (DEI) and effective Z (Z_eff)-were calculated, ranging from 0.0027 to 0.321 and from 6.89 to 13.02, respectively. Statistical analysis showed a significant correlation between the DEI and Z_eff values (P < .001). The interobserver intraclass correlation coefficient was 0.91 for the mean Z_eff values and 0.86 for the mean DEI values. This technique could potentially provide useful information regarding the composition of a CTO.

MeSH terms

Angiography
Chronic Disease
Feasibility Studies
Humans
Peripheral Arterial Disease* / diagnostic imaging
Peripheral Arterial Disease* / therapy
Tomography, X-Ray Computed* / methods