Triterpene constituents from the fruits of Cyclocarya paliurus and their anti-HIV-1IIIB activity

Wen-Chao Tu; Rong-Hua Luo; En Yuan; Kaunda-Joseph Sakah; Quan-Yu Yang; Wei-Lie Xiao; Yong-Tang Zheng; Mei-Feng Liu

doi:10.1080/14786419.2022.2120874

Triterpene constituents from the fruits of Cyclocarya paliurus and their anti-HIV-1_IIIB activity

Nat Prod Res. 2023 Jun;37(11):1787-1796. doi: 10.1080/14786419.2022.2120874. Epub 2022 Sep 12.

Authors

Wen-Chao Tu^{1

2}, Rong-Hua Luo³, En Yuan¹, Kaunda-Joseph Sakah², Quan-Yu Yang², Wei-Lie Xiao², Yong-Tang Zheng³, Mei-Feng Liu¹

Affiliations

¹ Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China.
² Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming, China.
³ Key Laboratory of Bioactive Peptides of Yunnan Province & Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.

PMID: 36095038
DOI: 10.1080/14786419.2022.2120874

Abstract

Four new norceanothane-type triterpenes, cyclopalin A-D (1-4), and sixteen known compounds (5-20) were obtained from the fruits of Cyclocarya paliurus. Their structures were determined by spectroscopic data, experimental electronic circular dichroism (ECD) and X-ray single crystal analyses. All isolated compounds were assayed for their anti-HIV-1_IIIB activity. Compound 18 exhibited potent anti-HIV-1_IIIB activity with an EC₅₀ value of 1.32 μM (SI = 151.52).

Keywords: Cyclocarya paliurus; Juglandaceae; anti-HIV-1IIIB activity; norceanothane-type triterpenes.

MeSH terms

Fruit
Juglandaceae* / chemistry
Plant Leaves / chemistry
Spectrum Analysis
Triterpenes* / chemistry

Substances

Triterpenes