Benzoquinone and furopyridinone derivatives from the marine-derived fungus Talaromyces sp. MCCC 3A01752

Xuan Hong; Lingzhi Tang; Zhongwei Chen; Qiliang Lai; Beibei Zhang; Youwei Jiang; Xunjie Wang; Ruonan He; Jianhui Lin; Zongze Shao; Shan Lin; Weiyi Wang

doi:10.1080/14786419.2022.2121830

Benzoquinone and furopyridinone derivatives from the marine-derived fungus Talaromyces sp. MCCC 3A01752

Nat Prod Res. 2024 Jan-Feb;38(2):320-326. doi: 10.1080/14786419.2022.2121830. Epub 2022 Sep 10.

Authors

Xuan Hong¹, Lingzhi Tang¹, Zhongwei Chen¹, Qiliang Lai², Beibei Zhang², Youwei Jiang¹, Xunjie Wang¹, Ruonan He¹, Jianhui Lin², Zongze Shao², Shan Lin^{3

4}, Weiyi Wang²

Affiliations

¹ Fujian Universities and Colleges Engineering Research Center of Marine Biopharmaceutical Resources, Xiamen Medical College, Xiamen, Fujian, China.
² Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, Fujian, China.
³ Department of Orthopedics, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
⁴ School of Medicine, Xiamen University, Xiamen, Fujian, China.

PMID: 36093561
DOI: 10.1080/14786419.2022.2121830

Abstract

Two new compounds, compounds 1 and 2, were obtained from the culture of a marine-derived fungus Talaromyces sp. MCCC 3A01752, together with 13 known compounds (3-15). Their structures were elucidated based on detailed analysis of NMR, HRESIMS, ECD spectra and OR value. Compound 1 exhibited antibacterial potential against Staphylococcus aureus with a MIC value of 100 μM and cytotoxic activity against gastric cancer cell line MKN1 with a IC₅₀ value of 78.0 μM.

Keywords: NMR; Talaromyces; antimicrobial; cytotoxic.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Antineoplastic Agents* / chemistry
Antineoplastic Agents* / pharmacology
Benzoquinones
Molecular Structure
Staphylococcus aureus
Talaromyces* / chemistry

Substances

Anti-Bacterial Agents
Antineoplastic Agents
quinone
Benzoquinones