Racial and ethnic characteristics and cancer-specific survival in Primary Malignant Cardiac Tumors

Mark M Aloysius; Sanskriti Shrivastava; Chaitanya Rojulpote; Raza Naseer; Hamza Hanif; Milos Babic; Kenneth Gentilezza; Pranjal K Boruah; Samir Pancholy

doi:10.3389/fcvm.2022.961160

Racial and ethnic characteristics and cancer-specific survival in Primary Malignant Cardiac Tumors

Front Cardiovasc Med. 2022 Aug 25:9:961160. doi: 10.3389/fcvm.2022.961160. eCollection 2022.

Authors

Mark M Aloysius¹, Sanskriti Shrivastava¹, Chaitanya Rojulpote¹, Raza Naseer¹, Hamza Hanif¹, Milos Babic¹, Kenneth Gentilezza², Pranjal K Boruah³, Samir Pancholy³

Affiliations

¹ Department of Internal Medicine, The Wright Center for Graduate Medical Education, Scranton, PA, United States.
² Department of Physical Medicine and Rehabilitation, The Wright Center for Graduate Medical Education, Scranton, PA, United States.
³ Department of Cardiovascular Diseases, The Wright Center for Graduate Medical Education, Scranton, PA, United States.

Abstract

Background: There is limited insight into the epidemiological characteristics and effect of race and ethnicity on Primary Malignant Cardiac Tumors (PMCTs).

Objectives: Comparison of clinical characteristics and cancer-specific survival outcomes of major races in the United States from the Surveillance, Epidemiology and End-Result (SEER) registry.

Methods: ICD-O-3 codes were used to identify PMCTs for the years 1975 to 2015. Three major races were identified-"White", "Black", and "Asian/Pacific Islander". Cancer-specific survival outcomes were compared using Kaplan-Meier analysis across and amongst races, based on tumor histology. A subgroup analysis of cancer-specific survival was performed between "Hispanics" and "non-Hispanics."

Results: Seven hundred and twenty patients were identified-47% females and 79% White, mean age at diagnosis (47 ± 20 years). Black patients were significantly younger (39 ± 18 years) and presented more commonly with angiosarcomas (53%). Non-angiogenic sarcomas and lymphomas were the most common tumors in the White (38%) and Asian/Pacific Islander (34%) cohorts. For a median follow-up period of 50 (IQR3-86) months, cancer-specific survival (mean ± SD, in months) was worse in Blacks (9 ± 3) as compared to Whites (15 ± 1) and Asian/Pacific Islander (14 ± 1) (p-value; Black vs. White <0.001; Black vs. Asian/Pacific Islanders = 0.017, White vs. Asian/Pacific Islanders = 0.3). Subgroup analysis with 116 (16%) Hispanics (40% females; mean age of 40 ± 20 years) showed a longer mean cancer-specific survival of 16.9 ± 2.4 months as compared to 13.6 ± 1.1 months in non-Hispanics (p = 0.011).

Conclusion: Black and non-Hispanic patients have poorer cancer-specific survival in PMCTs.

Keywords: Primary Malignant Cardiac Tumors; disparities; epidemiology; ethnicity; outcomes; race; risk factor.