The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling

Kun Zhao; Yukang Mao; Yansong Li; Chuanxi Yang; Kai Wang; Jing Zhang

doi:10.3389/fcvm.2022.952949

The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling

Front Cardiovasc Med. 2022 Aug 26:9:952949. doi: 10.3389/fcvm.2022.952949. eCollection 2022.

Authors

Kun Zhao¹, Yukang Mao¹, Yansong Li¹, Chuanxi Yang^{1

2}, Kai Wang¹, Jing Zhang¹

Affiliations

¹ Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
² Department of Cardiology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China.

Abstract

Pathological myocardial remodeling was still one of the leading causes of death worldwide with an unmet therapeutic need. A growing number of researchers have addressed the role of epigenome changes in cardiovascular diseases, paving the way for the clinical application of novel cardiovascular-related epigenetic targets in the future. In this review, we summarized the emerged advances of epigenetic regulation, including DNA methylation, Histone posttranslational modification, Adenosine disodium triphosphate (ATP)-dependent chromatin remodeling, Non-coding RNA, and RNA modification, in pathological myocardial remodeling. Also, we provided an overview of the mechanisms that potentially involve the participation of these epigenetic regulation.

Keywords: DNA methylation; RNA modification; adenosine disodium triphosphate (ATP)-dependent chromatin remodeling; epigenetic regulation; histone posttranslational modification; pathological myocardial remodeling.

Publication types

Review