Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma

Hao Zhang; Nan Zhang; Wantao Wu; Zeyu Wang; Ziyu Dai; Xisong Liang; Liyang Zhang; Yun Peng; Peng Luo; Jian Zhang; Zaoqu Liu; Quan Cheng; Zhixiong Liu

doi:10.1016/j.isci.2022.104918

Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma

iScience. 2022 Aug 10;25(9):104918. doi: 10.1016/j.isci.2022.104918. eCollection 2022 Sep 16.

Authors

Hao Zhang^{1

2

3}, Nan Zhang^{1

4

2}, Wantao Wu^{5

2}, Zeyu Wang^{1

2}, Ziyu Dai^{1

2}, Xisong Liang^{1

2}, Liyang Zhang^{1

2}, Yun Peng^{6

7

2}, Peng Luo⁸, Jian Zhang⁸, Zaoqu Liu⁹, Quan Cheng^{1

2}, Zhixiong Liu^{1

2}

Affiliations

¹ Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
² National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
³ Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
⁴ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
⁵ Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.
⁶ Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China.
⁷ Teaching and Research Section of Clinical Nursing, Xiangya Hospital, Central South University, Changsha, China.
⁸ Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
⁹ Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Abstract

Microenvironment cells (MCs) play a critical role in tumor proliferation, progression, and metastasis. However, it has not been adequately addressed whether MCs could be used as a reliable prognostic marker in glioblastoma (GBM). In the current study, the cell pair (CP) score was constructed in 1137 GBM samples based on the cell pair algorithm and Gaussian finite mixture model (GMM) and was verified in 73 GBM samples from the Xiangya cohort. CP score predicted GBM patients' survival and response to anti-PD-1 treatment with high sensitivity. Macrophage markers CD68 and CD163 were co-expressed with pericyte markers MCAM and MG2. Pericyte could mediate the infiltration, migration, and M2 type polarization of macrophages by MCAM. The CP score was a valuable tool for predicting survival outcomes and guiding immunotherapy for GBM patients. Cell pair pericyte/macrophage and gene pair CD163/MCAM were biologically significant in the tumor microenvironment of GBM.

Keywords: Biocomputational method; Cancer; Genomic analysis; Immunology.