Recent developments in one-pot stepwise synthesis (OPSS) of small molecules

Xiaoming Ma; Wei Zhang

doi:10.1016/j.isci.2022.105005

Recent developments in one-pot stepwise synthesis (OPSS) of small molecules

iScience. 2022 Aug 27;25(9):105005. doi: 10.1016/j.isci.2022.105005. eCollection 2022 Sep 16.

Authors

Xiaoming Ma¹, Wei Zhang²

Affiliations

¹ School of Pharmacy, Changzhou University, Jiangsu 213164, China.
² Department of Chemistry, University of Massachusetts Boston, MA 02125, USA.

Abstract

One-pot synthesis is an active topic in organic chemistry due to its intrinsic advantages of simple operation, high mass efficiency, low cost, and less amount of waste disposal. Among three kinds of one-pot syntheses, 1) cascade reactions, 2) multicomponent reactions (MCRs), and 3) one-pot stepwise synthesis (OPSS), OPSS could be more flexible and practical since it is carried out stepwisely and have variable reaction conditions for different steps. This perspective article uses selected examples to highlight the recent development in OPSS involving cyclization, cycloaddition, rearrangement, and catalytic reactions for the synthesis of heterocyclic scaffolds, asymmetric molecules, natural products, and bioactive compounds.

Keywords: Chemistry; Green chemistry; Organic chemistry.

Publication types

Review