Two-stage skin grafting using a basic fibroblast growth factor-impregnated artificial dermis

Ryushiro Sugimoto; Hiroki Yamanaka; Itaru Tsuge; Yasuhiro Katayama; Motoki Katsube; Michiharu Sakamoto; Naoki Morimoto

doi:10.1016/j.reth.2022.07.013

Two-stage skin grafting using a basic fibroblast growth factor-impregnated artificial dermis

Regen Ther. 2022 Aug 23:21:258-262. doi: 10.1016/j.reth.2022.07.013. eCollection 2022 Dec.

Authors

Ryushiro Sugimoto¹, Hiroki Yamanaka¹, Itaru Tsuge¹, Yasuhiro Katayama¹, Motoki Katsube¹, Michiharu Sakamoto¹, Naoki Morimoto¹

Affiliation

¹ Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

Abstract

For traditional artificial dermises, a waiting period of approximately three weeks is required after the first implantation before they are adequately vascularized. The objective of this retrospective case series was to investigate whether full-thickness skin defects, requiring surgical reconstruction, could be successfully treated by implantation of a basic fibroblast growth factor (bFGF)-impregnated artificial dermis and secondary skin grafting with a shorter waiting period. Between January 2019 and January 2021, 19 skin defects in 14 patients (7 male and 7 female) were treated with two-stage skin grafting using bFGF-impregnated collagen-gelatin sponge (CGS). All of them were included in this case series, and the waiting period for skin grafting, success rate of skin grafting, infection during the waiting period, and scar quality 6-12 months postoperatively were retrospectively investigated. As a result, all skin grafting surgeries were successfully performed with a waiting period of 13.3 ± 4.3 days. Infection during the waiting period was observed in three lesions (15.8%); however, all infections were controllable. Postoperative scar quality was acceptable (Vancouver Scar Scale score range, 1-8). In conclusion, compared to traditional artificial dermises, bFGF-impregnated CGSs have the potential to shorten the waiting period without decreasing the success rate of skin grafting. Further studies are required to confirm this finding.

Keywords: Artificial dermis; Basic fibroblast growth factor; CGS, collagen-gelatin sponge; GCMN, giant congenital melanocytic nevus; MRSA, methicillin-resistant Staphylococcus aureus; Two-stage skin grafting; VSS, Vancouver Scar Scale; Waiting period; bFGF, basic fibroblast growth factor.