Omics technologies to understand drug toxicity mechanisms

Nhan Nguyen; Danyel Jennen; Jos Kleinjans

doi:10.1016/j.drudis.2022.103348

Omics technologies to understand drug toxicity mechanisms

Drug Discov Today. 2022 Nov;27(11):103348. doi: 10.1016/j.drudis.2022.103348. Epub 2022 Sep 8.

Authors

Nhan Nguyen¹, Danyel Jennen², Jos Kleinjans¹

Affiliations

¹ Department of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, Maastricht 6229ER, the Netherlands.
² Department of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, Maastricht 6229ER, the Netherlands. Electronic address: danyel.jennen@maastrichtuniversity.nl.

PMID: 36089240
DOI: 10.1016/j.drudis.2022.103348

Abstract

Drug side effects are an important study subject in pharmacology. Recent omics technologies provide a range of omics data and help to understand the biological mechanisms involved in drug effects. These modern technologies provide significant support to all biological disciplines, including drug toxicology. In this review, we provide an overview the use of omics applications to understand drug side effects at the molecular level. We discuss by available omics technologies, their possible uses, as well as their advantages and limitations.

Keywords: Drug safety; Drug side effects; Omics; Toxicogenomics.

Publication types

Review