Drug-induced acne with elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis

Abstract

Elexacaftor/tezacaftor/ivacaftor (ELX-TEZ-IVA) is a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulator shown to improve lung function and reduce sweat chloride in people with Cystic Fibrosis (CF). The only commonly reported dermatologic adverse effect with CFTR modulators including ELX-TEZ-IVA is rash. In this case series, we describe 19 patients who reported new onset or worsening of acne after initiation of this drug to their CF pharmacist or another member of their CF care team. The mechanism and frequency of this adverse effect is unknown.

Keywords: “Acne vulgaris”; “Cystic fibrosis”; “Drug-Related side effects and adverse reactions”; “Elexacaftor”.